• Whereas SimCity simulates traffic and the life of your city by means of complex algorithms (i.e.: in a zone there are 100,000 inhabitants, so traffic is 70. If the road besides only holds a traffic of 60, that road jams), Cities Skylines simulates every person in the city individually (in fact, you can change their names, the names of their cars, etc.), and those people take their vehicles, and those vehicles, if they are too many, eventually jam the roads. This concept, yet leading to unrealistic situations, is to me awesome.
• Cities Skylines has pretty decent district mechanics. You can design your own districts, and make specific laws for those districts. Industrial areas can be classified as regular, oil industry, wood industry, agricultural industry and mineral industry. Each industry has its own characteristics, and use up its own natural resources. For example, in order to make wood industry, you need forests; to assign successfully oil industry, you need to have oil deposits inside your city limits; etc. Finally, regular industry consumes all those prime resources in order to make products for your commercials to sell. Also, there are a punch of different laws you can apply either for your entire city or just for a specific district.
The only thing I see you would prefer playing SimCity is that, as mentioned, traffic and city planning in that game is much more realistic, that you can trade with your neighbours and, of course, multiplayer. But anyway, if you are a fan of city planning games, you must buy this one!